Quantification of the Resveratrol Analogs trans-2,3-Dimethoxy-stilbene and trans-3,4-Dimethoxystilbene in Rat Plasma: Application to Pre-Clinical Pharmacokinetic Studies

Quantification of the Resveratrol Analogs trans-2,3-Dimethoxy-stilbene and trans-3,4-Dimethoxystilbene in Rat Plasma: Application to Pre-Clinical Pharmacokinetic Studies

trans-2,3-Dimethoxystilbene (2,3-DMS) and trans-3,4-dimethoxystilbene (3,4-DMS) are two synthetic resveratrol (trans-3,5,4'-trihydroxystilbene) analogs. In this study, a simple HPLC method was developed and validated to determine 2,3-DMS and 3,4-DMS in rat plasma. Chromatographic separation w...

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Bibliographic Details
Main Authors: Shermain Yali Ng, Nunzio Cardullo, Samuel Chao Ming Yeo, Carmela Spatafora, Corrado Tringali, Pei-Shi Ong, Hai-Shu Lin
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
resveratrol
trans-2,3-dimethoxystilbene
trans-3,4-dimethoxystilbene
HPLC
pharmacokinetics
Online Access:http://www.mdpi.com/1420-3049/19/7/9577

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http://www.mdpi.com/1420-3049/19/7/9577

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