The Effect of Chronic Mild Stress and Escitalopram on the Expression and Methylation Levels of Genes Involved in the Oxidative and Nitrosative Stresses as Well as Tryptophan Catabolites Pathway in the Blood and Brain Structures

The Effect of Chronic Mild Stress and Escitalopram on the Expression and Methylation Levels of Genes Involved in the Oxidative and Nitrosative Stresses as Well as Tryptophan Catabolites Pathway in the Blood and Brain Structures

Previous studies suggest that depression may be associated with reactive oxygen species overproduction and disorders of the tryptophan catabolites pathway. Moreover, one-third of patients do not respond to conventional pharmacotherapy. Therefore, the study investigates the molecular effect of escita...

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Bibliographic Details
Main Authors: Paulina Wigner, Ewelina Synowiec, Paweł Jóźwiak, Piotr Czarny, Michał Bijak, Katarzyna Białek, Janusz Szemraj, Piotr Gruca, Mariusz Papp, Tomasz Śliwiński
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
depression
chronic mild stress
oxidative stress
tryptophan catabolites pathway
methylation
expression
Online Access:https://www.mdpi.com/1422-0067/22/1/10

Internet

https://www.mdpi.com/1422-0067/22/1/10

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