Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

Post-injury epilepsy (PIE) is a common complication following brain insults, including ischemic, and traumatic brain injuries. At present, there are no means to identify the patients at risk to develop PIE or to prevent its development. Seizures can occur months or years after the insult, do not res...

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Bibliographic Details
Main Authors: Itai Weissberg, Lydia Wood, Lyn Kamintsky, Oscar Vazquez, Dan Z. Milikovsky, Allyson Alexander, Hannah Oppenheim, Carolyn Ardizzone, Albert Becker, Federica Frigerio, Annamaria Vezzani, Marion S. Buckwalter, John R. Huguenard, Alon Friedman, Daniela Kaufer
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Albumin
TGF-β
Synaptogenesis
Blood–brain barrier (BBB)
Seizures
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000972

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http://www.sciencedirect.com/science/article/pii/S0969996115000972

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