CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma

CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma

PurposeSorafenib is a multi-kinase inhibitor that is used as a standard treatment for advanced hepatocellular carcinoma (HCC). However, the mechanism of sorafenib resistance in HCC is still unclear. It has been shown that CISD2 expression is related to the progression and poor prognosis of HCC. Here...

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Bibliographic Details
Main Authors: Bowen Li, Shibo Wei, Liang Yang, Xueqiang Peng, Yingbo Ma, Bo Wu, Qing Fan, Shuo Yang, Xinyu Li, Hongyuan Jin, Shilei Tang, Mingyao Huang, Hangyu Li, Jingang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
sorafenib resistance
ferroptosis
CISD2
autophagy
Beclin1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.657723/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.657723/full

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