Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology

Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology

Abstract Background This study was to investigate the effect and its possible mechanism of fucoidan on the development of spontaneous autoimmune diabetes in non-obese diabetic (NOD) mice. Methods 7-week-old NOD mice were randomly divided into three groups: control group, low-dose (300 mg/kg) and hig...

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Bibliographic Details
Main Authors: Meilan Xue, Hui Liang, Xinqiang Ji, Ying Liu, Yinlin Ge, Lin Hou, Ting Sun
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Nutrition & Metabolism
Subjects:
Type 1 diabetes
Non-obese diabetic mice
Fucoidan
Immune tolerance
Gut microecology
Online Access:https://doi.org/10.1186/s12986-019-0392-1

Internet

https://doi.org/10.1186/s12986-019-0392-1

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