A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia

A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia

The fine regulation of intracellular calcium is fundamental for all eukaryotic cells. In neurons, Ca2+ oscillations govern the synaptic development, the release of neurotransmitters and the expression of several genes. Alterations of Ca2+ homeostasis were found to play a pivotal role in neurodegener...

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Bibliographic Details
Main Authors: Mattia Vicario, Ginevra Zanni, Francesca Vallese, Filippo Santorelli, Alessandro Grinzato, Domenico Cieri, Paola Berto, Martina Frizzarin, Raffaele Lopreiato, Francesco Zonta, Stefania Ferro, Michele Sandre, Oriano Marin, Maria Ruzzene, Enrico Bertini, Giuseppe Zanotti, Marisa Brini, Tito Calì, Ernesto Carafoli
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Neurobiology of Disease
Subjects:
Calcium signaling
Plasma membrane calcium ATPases
Cerebellar ataxia
Pump mutation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301177

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http://www.sciencedirect.com/science/article/pii/S0969996118301177

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