Inhibitors of pathogen intercellular signals as selective anti-infective compounds.

Inhibitors of pathogen intercellular signals as selective anti-infective compounds.

Long-term antibiotic use generates pan-resistant super pathogens. Anti-infective compounds that selectively disrupt virulence pathways without affecting cell viability may be used to efficiently combat infections caused by these pathogens. A candidate target pathway is quorum sensing (QS), which man...

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Bibliographic Details
Main Authors: Biliana Lesic, François Lépine, Eric Déziel, Jiangwen Zhang, Qunhao Zhang, Katie Padfield, Marie-Hélène Castonguay, Sylvain Milot, Scott Stachel, A Aria Tzika, Ronald G Tompkins, Laurence G Rahme
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2323289?pdf=render

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http://europepmc.org/articles/PMC2323289?pdf=render

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