Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus.

Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus.

Podocyte or endothelial cell VEGF-A knockout causes thrombotic microangiopathy in adult mice. To study the mechanism involved in acute and local injury caused by low podocyte VEGF-A we developed an inducible, podocyte-specific VEGF-A knockdown mouse, and we generated an immortalized podocyte cell li...

Full description

Bibliographic Details
Main Authors: Delma Veron, Guillermo Villegas, Pardeep Kumar Aggarwal, Claudia Bertuccio, Juan Jimenez, Heino Velazquez, Kimberly Reidy, Dale R Abrahamson, Gilbert Moeckel, Michael Kashgarian, Alda Tufro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3396653?pdf=render

Internet

http://europepmc.org/articles/PMC3396653?pdf=render

Similar Items