VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease

Mutations in vacuolar protein sorting 35 (VPS35) have been linked to familial Parkinson's disease (PD). VPS35, a component of the retromer, mediates the retrograde transport of cargo from the endosome to the trans-Golgi network. Here we showed that retromer depletion increases the lysosomal tur...

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Bibliographic Details
Main Authors: Emiko Miura, Takafumi Hasegawa, Masatoshi Konno, Mari Suzuki, Naoto Sugeno, Nobuhiro Fujikake, Sven Geisler, Mitsuaki Tabuchi, Ryuji Oshima, Akio Kikuchi, Toru Baba, Keiji Wada, Yoshitaka Nagai, Atsushi Takeda, Masashi Aoki
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
VPS35
α-Synuclein
Retromer
Cathepsin D
Lysosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002150

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http://www.sciencedirect.com/science/article/pii/S0969996114002150

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