Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins

Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins

Triple-negative breast cancer (TNBC) is more aggressive and has poorer prognosis compared to other subtypes of breast cancer. Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells transform into mesenchymal-like cells capable of migration, invasion, and metastasis. Recent...

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Bibliographic Details
Main Authors: Chanjuan Zheng, Shichao Yan, Lu Lu, Hui Yao, Guangchun He, Sisi Chen, Ying Li, Xiaojun Peng, Zhongyi Cheng, Mi Wu, Qiuting Zhang, Guifei Li, Shujun Fu, Xiyun Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
lovastatin
triple-negative breast cancer
cancer stem cells
epithelial-to-mesenchymal transition
cytoskeleton
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.656687/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.656687/full

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