Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice

Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice

Osteopontin (OPN) is a secreted phosphoglycoprotein, and is a transcriptional target of aberrant Wnt signaling. OPN is upregulated in human colon cancers, and is suggested to enhance cancer progression. In this study, the effect of deficiency of OPN on intestinal tumor development in Apc-deficient M...

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Bibliographic Details
Main Authors: Rikako Ishigamori, Masami Komiya, Shinji Takasu, Michihiro Mutoh, Toshio Imai, Mami Takahashi
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:International Journal of Molecular Sciences
Subjects:
osteopontin
colorectal tumor
macrophage
Online Access:http://www.mdpi.com/1422-0067/18/5/1058

Internet

http://www.mdpi.com/1422-0067/18/5/1058

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