Deletion of the Ca2+ Channel Subunit α2δ3 Differentially Affects Cav2.1 and Cav2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing

Deletion of the Ca2+ Channel Subunit α2δ3 Differentially Affects Cav2.1 and Cav2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing

Voltage-gated Ca2+ channels are composed of a pore-forming α1 subunit and auxiliary β and α2δ subunits, which modulate Ca2+ current properties and channel trafficking. So far, the partial redundancy and specificity of α1 for α2δ subunits in the CNS have remained largely elusive. Mature spiral gangli...

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Bibliographic Details
Main Authors: Friederike Stephani, Veronika Scheuer, Tobias Eckrich, Kerstin Blum, Wenying Wang, Gerald J. Obermair, Jutta Engel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Ca2+ channel
Ca2+ current
P/Q-type
N-type
postnatal development
auditory
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00278/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00278/full

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