The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.

Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxaborole-based compounds are very promising potential novel anti-trypanosomal therapies, with candidates...

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Bibliographic Details
Main Authors: Daniela Begolo, Isabel M Vincent, Federica Giordani, Ina Pöhner, Michael J Witty, Timothy G Rowan, Zakaria Bengaly, Kirsten Gillingwater, Yvonne Freund, Rebecca C Wade, Michael P Barrett, Christine Clayton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007315

Internet

https://doi.org/10.1371/journal.ppat.1007315

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