A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.
IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma. Through whole-geno...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-03-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC5362243?pdf=render |