Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging

Ionizing radiation (IR) is a common mode of cancer therapy, where DNA damage is the major reason of cell death. Here, we use an assay based on fluorescence imaging of single damaged DNA molecules isolated from radiated lymphocytes, to quantify IR induced DNA damage. The assay uses a cocktail of DNA-...

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Bibliographic Details
Main Authors: Vandana Singh, Pegah Johansson, Dmitry Torchinsky, Yii-Lih Lin, Robin Öz, Yuval Ebenstein, Ola Hammarsten, Fredrik Westerlund
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320303144