HDL and CER-001 Inverse-Dose Dependent Inhibition of Atherosclerotic Plaque Formation in apoE-/- Mice: Evidence of ABCA1 Down-Regulation.

HDL and CER-001 Inverse-Dose Dependent Inhibition of Atherosclerotic Plaque Formation in apoE-/- Mice: Evidence of ABCA1 Down-Regulation.

CER-001 is a novel engineered HDL-mimetic comprised of recombinant human apoA-I and charged phospholipids that was designed to mimic the beneficial properties of nascent pre-ß HDL. In this study, we have evaluated the dose-dependent regulation of ABCA1 expression in vitro and in vivo in the presence...

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Bibliographic Details
Main Authors: Claudine Tardy, Marine Goffinet, Nadia Boubekeur, Guy Cholez, Rose Ackermann, Gavin Sy, Constance Keyserling, Narendra Lalwani, John F Paolini, Jean-Louis Dasseux, Ronald Barbaras, Rudi Baron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4559410?pdf=render

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http://europepmc.org/articles/PMC4559410?pdf=render

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