Three-Dimensional Light Sheet Fluorescence Microscopy of Lungs To Dissect Local Host Immune-Aspergillus fumigatus Interactions

Three-Dimensional Light Sheet Fluorescence Microscopy of Lungs To Dissect Local Host Immune-Aspergillus fumigatus Interactions

The use of animal models of infection is essential to advance our understanding of the complex host-pathogen interactions that take place during Aspergillus fumigatus lung infections. As in the case of humans, mice need to suffer an immune imbalance in order to become susceptible to invasive pulmona...

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Bibliographic Details
Main Authors: Jorge Amich, Zeinab Mokhtari, Marlene Strobel, Elena Vialetto, Dalia Sheta, Yidong Yu, Julia Hartweg, Natarajaswamy Kalleda, Katja J. Jarick, Christian Brede, Ana-Laura Jordán-Garrote, Sina Thusek, Katharina Schmiedgen, Berkan Arslan, Jürgen Pinnecker, Christopher R. Thornton, Matthias Gunzer, Sven Krappmann, Hermann Einsele, Katrin G. Heinze, Andreas Beilhack
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
aspergillus fumigatus
invasive aspergillosis
host-pathogen interactions
lung infection
lung immunity
microscopy/imaging
host immune response
light sheet fluorescence microscopy
murine models of invasive pulmonary aspergillosis
in vivo fungal growth
whole-organ imaging
Online Access:https://doi.org/10.1128/mBio.02752-19

Internet

https://doi.org/10.1128/mBio.02752-19

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