Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

Activation of the NLRP3 inflammasome triggers the production of inflammatory cytokines. Here, the authors inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and show that administration in mice is effective in preventing septic shock and peritonitis, and in improving di...

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Bibliographic Details
Main Authors: Congfei Xu, Zidong Lu, Yingli Luo, Yang Liu, Zhiting Cao, Song Shen, Hongjun Li, Jing Liu, Kaige Chen, Zhiyao Chen, Xianzhu Yang, Zhen Gu, Jun Wang
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06522-5

Internet

https://doi.org/10.1038/s41467-018-06522-5

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