Functional and molecular effects of TNF-α on human iPSC-derived cardiomyocytes

Functional and molecular effects of TNF-α on human iPSC-derived cardiomyocytes

Proinflammatory molecule tumor necrosis factor alpha (TNF-α) is predominantly elevated in cytokine storm as well as worsening cardiac function. Here we model the molecular and functional effects of TNF-α in cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSC). We found that...

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Bibliographic Details
Main Authors: Anita Saraf, Antonio Rampoldi, Myra Chao, Dong Li, Lawrence Armand, Hyun Hwang, Rui Liu, Rajnesh Jha, Haian Fu, Joshua T. Maxwell, Chunhui Xu
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Stem Cell Research
Subjects:
Human iPSC
Cardiomyocytes
Cytokines
Ca2+ transients
TNFα
Ca2+propagation
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121000647

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http://www.sciencedirect.com/science/article/pii/S1873506121000647

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