The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology

The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology

The fragile X mental retardation protein (FMRP), an RNA-binding protein that mediates the transport, stability, and translation of hundreds of brain RNAs, is critically involved in regulating synaptic function. Loss of FMRP, as in fragile X syndrome (FXS), is a leading monogenic cause of autism and...

Full description

Bibliographic Details
Main Authors: Jessica L. Huebschman, Kitzia S. Corona, Yuhong Guo, Laura N. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
striatum
dendritic spine
RNA-binding proteins
FXS
synapse structure
morphology
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00161/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00161/full

Similar Items