T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo

T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo

The cyclin-dependent kinase 6 (CDK6) regulates the transition through the G1-phase of the cell cycle, but also acts as a transcriptional regulator. As such CDK6 regulates cell survival or cytokine secretion together with STATs, AP-1 or NF-κB. In the hematopoietic system, CDK6 regulates T cell develo...

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Bibliographic Details
Main Authors: Klara Klein, Agnieszka Witalisz-Siepracka, Dagmar Gotthardt, Benedikt Agerer, Felix Locker, Reinhard Grausenburger, Vanessa Maria Knab, Andreas Bergthaler, Veronika Sexl
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
CDK6
CD8+ T cells
metabolism
interferon signaling
suppressor of cytokine signaling (SOCS)
anti-viral response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.650977/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.650977/full

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