T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo

T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo

The cyclin-dependent kinase 6 (CDK6) regulates the transition through the G1-phase of the cell cycle, but also acts as a transcriptional regulator. As such CDK6 regulates cell survival or cytokine secretion together with STATs, AP-1 or NF-κB. In the hematopoietic system, CDK6 regulates T cell develo...

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Bibliographic Details
Main Authors:	Klara Klein, Agnieszka Witalisz-Siepracka, Dagmar Gotthardt, Benedikt Agerer, Felix Locker, Reinhard Grausenburger, Vanessa Maria Knab, Andreas Bergthaler, Veronika Sexl
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Series:	Frontiers in Immunology
Subjects:	CDK6 CD8+ T cells metabolism interferon signaling suppressor of cytokine signaling (SOCS) anti-viral response
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.650977/full

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