Stochastic E2F activation and reconciliation of phenomenological cell-cycle models.

The transition of the mammalian cell from quiescence to proliferation is a highly variable process. Over the last four decades, two lines of apparently contradictory, phenomenological models have been proposed to account for such temporal variability. These include various forms of the transition pr...

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Bibliographic Details
Main Authors: Tae J Lee, Guang Yao, Dorothy C Bennett, Joseph R Nevins, Lingchong You
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2943438?pdf=render