Structural and Functional Insight Into the Glycosylation Impact Upon the HGF/c-Met Signaling Pathway

Structural and Functional Insight Into the Glycosylation Impact Upon the HGF/c-Met Signaling Pathway

Upon interactions with its specific ligand hepatocyte growth factor (HGF), the c-Met signal is relayed to series of downstream pathways, exerting essential biological roles. Dysregulation of the HGF-c-Met signaling pathway has been implicated in the onset, progression and metastasis of various cance...

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Bibliographic Details
Main Authors: Xinyue Hu, Feiyu Tang, Peilin Liu, Taowei Zhong, Fengyan Yuan, Quanyuan He, Mark von Itzstein, Hao Li, Liang Weng, Xing Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HGF
c-Met
glycosylation
cancer
application
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00490/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00490/full

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