Early Growth Response Gene-1 Suppresses Foot-and-Mouth Disease Virus Replication by Enhancing Type I Interferon Pathway Signal Transduction

Early Growth Response Gene-1 Suppresses Foot-and-Mouth Disease Virus Replication by Enhancing Type I Interferon Pathway Signal Transduction

Early growth response gene-1 (EGR1) is a multifunctional transcription factor that is implicated in viral infection. In this study, we observed that foot-and-mouth disease virus (FMDV) infection significantly triggered EGR1 expression. Overexpression of EGR1 suppressed FMDV replication in porcine ce...

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Bibliographic Details
Main Authors: Zixiang Zhu, Xiaoli Du, Pengfei Li, Xiangle Zhang, Fan Yang, Weijun Cao, Hong Tian, Keshan Zhang, Xiangtao Liu, Haixue Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Microbiology
Subjects:
foot-and-mouth disease virus
early growth response gene-1
interferon
viral replication
antiviral response
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02326/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02326/full

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