Insights on the trafficking and retro-translocation of ganglioside-binding bacterial toxins

Insights on the trafficking and retro-translocation of ganglioside-binding bacterial toxins

Some bacterial toxins and viruses have evolved the capacity to bind mammalian glycosphingolipids to gain access to the cell interior, where they can co-opt the endogenous mechanisms of cellular trafficking and protein translocation machinery to cause toxicity. Cholera toxin (CT) is one of the best-s...

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Bibliographic Details
Main Authors: Jin Ah Cho, Daniel J.-F. Chinnapen, Emil eAamar, Yvonne Maria te Welscher, Wayne eLencer, Ramiro eMassol
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Cholera Toxin
Membrane trafficking
ERAD
retro-translocation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00051/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00051/full

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