Insights on the trafficking and retro-translocation of ganglioside-binding bacterial toxins
Some bacterial toxins and viruses have evolved the capacity to bind mammalian glycosphingolipids to gain access to the cell interior, where they can co-opt the endogenous mechanisms of cellular trafficking and protein translocation machinery to cause toxicity. Cholera toxin (CT) is one of the best-s...
Main Authors: | Jin Ah Cho, Daniel J.-F. Chinnapen, Emil eAamar, Yvonne Maria te Welscher, Wayne eLencer, Ramiro eMassol |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2012-04-01
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Series: | Frontiers in Cellular and Infection Microbiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00051/full |
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