Impact of a Complement Factor H Gene Variant on Renal Dysfunction, Cardiovascular Events, and Response to ACE Inhibitor Therapy in Type 2 Diabetes

Impact of a Complement Factor H Gene Variant on Renal Dysfunction, Cardiovascular Events, and Response to ACE Inhibitor Therapy in Type 2 Diabetes

Complement activation has been increasingly implicated in the pathogenesis of type 2 diabetes and its chronic complications. It is unknown whether complement factor H (CFH) genetic variants, which have been previously associated with complement-mediated organ damage likely due to inefficient complem...

Full description

Bibliographic Details
Main Authors: Elisabetta Valoti, Marina Noris, Annalisa Perna, Erica Rurali, Giulia Gherardi, Matteo Breno, Aneliya Parvanova Ilieva, Ilian Petrov Iliev, Antonio Bossi, Roberto Trevisan, Alessandro Roberto Dodesini, Silvia Ferrari, Nadia Stucchi, Ariela Benigni, Giuseppe Remuzzi, Piero Ruggenenti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Genetics
Subjects:
diabetes
complement
factor H
ACE inhibitors
microalbuminuria
cardiovascular risk
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00681/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00681/full

Similar Items