Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial
Abstract Background Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product...
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doaj-e1a14b3adaeb4711983cd1eda6b02a912020-11-25T00:32:15ZengBMCNutrition Journal1475-28912017-05-0116111510.1186/s12937-017-0249-2Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trialOonagh Markey0Dafni Vasilopoulou1Kirsty E. Kliem2Albert Koulman3Colette C. Fagan4Keith Summerhill5Laura Y. Wang6Alistair S. Grandison7David J. Humphries8Susan Todd9Kim G. Jackson10David I. Givens11Julie A. Lovegrove12Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of ReadingHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of ReadingAnimal, Dairy and Food Chain Sciences, University of ReadingMRC Elsie Widdowson LaboratoryDepartment of Food and Nutritional Sciences, University of ReadingMRC Elsie Widdowson LaboratoryMRC Elsie Widdowson LaboratoryDepartment of Food and Nutritional Sciences, University of ReadingAnimal, Dairy and Food Chain Sciences, University of ReadingDepartment of Mathematics and Statistics, School of Mathematical, Physical and Computational Sciences, University of ReadingHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of ReadingInstitute for Food, Nutrition and Health, University of ReadingHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of ReadingAbstract Background Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status. Methods In a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA). Results Following the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet. Conclusion The food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance. Trial registration ClinicalTrials.gov Identifier: NCT02089035 , date 05-01-2014.http://link.springer.com/article/10.1186/s12937-017-0249-2Cardiovascular diseaseDairy productsDietary fat compositionFood-exchange modelFatty acidsMonounsaturated fatty acids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Oonagh Markey Dafni Vasilopoulou Kirsty E. Kliem Albert Koulman Colette C. Fagan Keith Summerhill Laura Y. Wang Alistair S. Grandison David J. Humphries Susan Todd Kim G. Jackson David I. Givens Julie A. Lovegrove |
spellingShingle |
Oonagh Markey Dafni Vasilopoulou Kirsty E. Kliem Albert Koulman Colette C. Fagan Keith Summerhill Laura Y. Wang Alistair S. Grandison David J. Humphries Susan Todd Kim G. Jackson David I. Givens Julie A. Lovegrove Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial Nutrition Journal Cardiovascular disease Dairy products Dietary fat composition Food-exchange model Fatty acids Monounsaturated fatty acids |
author_facet |
Oonagh Markey Dafni Vasilopoulou Kirsty E. Kliem Albert Koulman Colette C. Fagan Keith Summerhill Laura Y. Wang Alistair S. Grandison David J. Humphries Susan Todd Kim G. Jackson David I. Givens Julie A. Lovegrove |
author_sort |
Oonagh Markey |
title |
Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial |
title_short |
Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial |
title_full |
Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial |
title_fullStr |
Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial |
title_full_unstemmed |
Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial |
title_sort |
plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial |
publisher |
BMC |
series |
Nutrition Journal |
issn |
1475-2891 |
publishDate |
2017-05-01 |
description |
Abstract Background Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status. Methods In a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA). Results Following the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet. Conclusion The food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance. Trial registration ClinicalTrials.gov Identifier: NCT02089035 , date 05-01-2014. |
topic |
Cardiovascular disease Dairy products Dietary fat composition Food-exchange model Fatty acids Monounsaturated fatty acids |
url |
http://link.springer.com/article/10.1186/s12937-017-0249-2 |
work_keys_str_mv |
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