FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury

FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury

Dendritic cells (DCs) are central in regulating immune responses of kidney ischemia-reperfusion injury (IRI), and strategies to alter DC function may provide new therapeutic opportunities. Sphingosine 1-phosphate (S1P) modulates immunity through binding to its receptors (S1P1-5), and protection from...

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Bibliographic Details
Main Authors: Thomas V. Rousselle, Canan Kuscu, Cem Kuscu, Kailo Schlegel, LiPing Huang, Maria Namwanje, James D. Eason, Liza Makowski, Daniel Maluf, Valeria Mas, Amandeep Bajwa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
FTY720
mitochondria
sphingosine-1-phosphate receptor
macrophages
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01278/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01278/full

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