FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator...

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Bibliographic Details
Main Authors: Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M Kessler, Haruhiko Koseki, Robert J Klose
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
chromatin
CpG islands
CDK-Mediator
ZF-CxxC
transcription
lineage commitment
Online Access:https://elifesciences.org/articles/37084

Internet

https://elifesciences.org/articles/37084

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