The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

by Hamish W King, Robert J Klose
Published 2017-03-01

Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

by Miles K. Huseyin, Robert J. Klose
Published 2021-02-01

Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins.

by Robert J Klose, Sarah Cooper, Anca M Farcas, Neil P Blackledge, Neil Brockdorff
Published 2013-01-01

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

by Emilia Dimitrova, Takashi Kondo, Angelika Feldmann, Manabu Nakayama, Yoko Koseki, Rebecca Konietzny, Benedikt M Kessler, Haruhiko Koseki, Robert J Klose
Published 2018-05-01

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

by Nathan R Rose, Hamish W King, Neil P Blackledge, Nadezda A Fursova, Katherine JI Ember, Roman Fischer, Benedikt M Kessler, Robert J Klose
Published 2016-10-01

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

by Hannah K Long, David Sims, Andreas Heger, Neil P Blackledge, Claudia Kutter, Megan L Wright, Frank Grützner, Duncan T Odom, Roger Patient, Chris P Ponting, Robert J Klose
Published 2013-02-01

Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes

by Hiroki Sugishita, Takashi Kondo, Shinsuke Ito, Manabu Nakayama, Nayuta Yakushiji-Kaminatsui, Eiryo Kawakami, Yoko Koseki, Yasuhide Ohinata, Jafar Sharif, Mio Harachi, Neil P. Blackledge, Robert J. Klose, Haruhiko Koseki
Published 2021-09-01

Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis

by Christina Ernst, Jeremy Pike, Sarah J Aitken, Hannah K Long, Nils Eling, Lovorka Stojic, Michelle C Ward, Frances Connor, Timothy F Rayner, Margus Lukk, Robert J Klose, Claudia Kutter, Duncan T Odom
Published 2016-11-01

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

by Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne
Published 2017-01-01

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

by Anca M Farcas, Neil P Blackledge, Ian Sudbery, Hannah K Long, Joanna F McGouran, Nathan R Rose, Sheena Lee, David Sims, Andrea Cerase, Thomas W Sheahan, Haruhiko Koseki, Neil Brockdorff, Chris P Ponting, Benedikt M Kessler, Robert J Klose
Published 2012-12-01

Correction: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

by Mitsuhiro Endoh, Takaho A Endo, Jun Shinga, Katsuhiko Hayashi, Anca Farcas, Kit-Wan Ma, Shinsuke Ito, Jafar Sharif, Tamie Endoh, Naoko Onaga, Manabu Nakayama, Tomoyuki Ishikura, Osamu Masui, Benedikt M Kessler, Toshio Suda, Osamu Ohara, Akihiko Okuda, Robert J Klose, Haruhiko Koseki
Published 2017-04-01

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

by Oliver N F King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R Rose, Stanley S Ng, Amy M Quinn, Ganesha Rai, Bryan T Mott, Paul Beswick, Robert J Klose, Udo Oppermann, Ajit Jadhav, Tom D Heightman, David J Maloney, Christopher J Schofield, Anton Simeonov
Published 2010-11-01

Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

by James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose
Published 2020-01-01

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

by David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose
Published 2017-09-01

Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction

by Dounia Djeghloul, Bhavik Patel, Holger Kramer, Andrew Dimond, Chad Whilding, Karen Brown, Anne-Céline Kohler, Amelie Feytout, Nicolas Veland, James Elliott, Tanmay A. M. Bharat, Abul K. Tarafder, Jan Löwe, Bee L. Ng, Ya Guo, Jacky Guy, Miles K. Huseyin, Robert J. Klose, Matthias Merkenschlager, Amanda G. Fisher
Published 2020-08-01