Development and Validation of Stability-Indicating HPLC Methods for the Estimation of Lomefloxacin and Balofloxacin Oxidation Process under ACVA, H<sub>2</sub>O<sub>2</sub>, or KMnO<sub>4</sub> Treatment. Kinetic Evaluation and Identification of Degradation Products by Mass Spectrometry

Development and Validation of Stability-Indicating HPLC Methods for the Estimation of Lomefloxacin and Balofloxacin Oxidation Process under ACVA, H<sub>2</sub>O<sub>2</sub>, or KMnO<sub>4</sub> Treatment. Kinetic Evaluation and Identification of Degradation Products by Mass Spectrometry

The oxidation of lomefloxacin (LOM) and balofloxacin (BAL) under the influence of azo initiator of radical reactions of 4,4′-azobis(4-cyanopentanoic acid) (ACVA) and H<sub>2</sub>O<sub>2</sub> was examined. Oxidation using H<sub>2</sub>O<sub>2</sub> wa...

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Bibliographic Details
Main Authors: Barbara Żuromska-Witek, Paweł Żmudzki, Marek Szlósarczyk, Anna Maślanka, Urszula Hubicka
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
balofloxacin
lomefloxacin
oxidation studies
kinetic evaluation
HPLC
Online Access:https://www.mdpi.com/1420-3049/25/22/5251

Internet

https://www.mdpi.com/1420-3049/25/22/5251

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