Rapid, simple, and clinically applicable high-performance liquid chromatography method for clinical determination of plasma colistin concentrations

Rapid, simple, and clinically applicable high-performance liquid chromatography method for clinical determination of plasma colistin concentrations

Abstract Background Since both the antibacterial effects and common adverse effects of colistin are concentration-dependent, determination of the most appropriate dosage regimen and administration method for colistin therapy is essential to ensure its efficacy and safety. We aimed to establish a rap...

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Bibliographic Details
Main Authors: Yuki Hanai, Kazuhiro Matsuo, Takayoshi Kosugi, Ayumu Kusano, Hayato Ohashi, Itsuki Kimura, Shinobu Hirayama, Yuta Nanjo, Yoshikazu Ishii, Takahiro Sato, Taito Miyazaki, Kenji Nishizawa, Takashi Yoshio
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Colistin
High-performance liquid chromatography
Fluorescence detection
9-fluorenylmethyl chloroformate
Therapeutic drug monitoring
Haemodialysis
Online Access:http://link.springer.com/article/10.1186/s40780-018-0119-x

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http://link.springer.com/article/10.1186/s40780-018-0119-x

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