Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

Abstract Background Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano-sized exosomes have shown great potential for promoting functional behavioral recovery following SCI. However,...

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Bibliographic Details
Main Authors: Wei Liu, Yuluo Rong, Jiaxing Wang, Zheng Zhou, Xuhui Ge, Chengyue Ji, Dongdong Jiang, Fangyi Gong, Linwei Li, Jian Chen, Shujie Zhao, Fanqi Kong, Changjiang Gu, Jin Fan, Weihua Cai
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord injury
Exosomes
Hypoxia
Microglia polarization
miR-216a-5p/TLR4 axis
Online Access:https://doi.org/10.1186/s12974-020-1726-7

Internet

https://doi.org/10.1186/s12974-020-1726-7

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