Finding a Potential Dipeptidyl Peptidase-4 (DPP-4) Inhibitor for Type-2 Diabetes Treatment Based on Molecular Docking, Pharmacophore Generation, and Molecular Dynamics Simulation

Finding a Potential Dipeptidyl Peptidase-4 (DPP-4) Inhibitor for Type-2 Diabetes Treatment Based on Molecular Docking, Pharmacophore Generation, and Molecular Dynamics Simulation

Dipeptidyl peptidase-4 (DPP-4) is the vital enzyme that is responsible for inactivating intestinal peptides glucagon like peptide-1 (GLP-1) and Gastric inhibitory polypeptide (GIP), which stimulates a decline in blood glucose levels. The aim of this study was to explore the inhibition activity of sm...

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Bibliographic Details
Main Authors: Harika Meduru, Yeng-Tseng Wang, Jeffrey J. P. Tsai, Yu-Ching Chen
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
incretin
GLP-1
GIP
DPP-4 inhibitors
type-2 diabetes
CDOCKER
pharmacophore generation
molecular dynamics simulation
Online Access:http://www.mdpi.com/1422-0067/17/6/920

Internet

http://www.mdpi.com/1422-0067/17/6/920

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