The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development

The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development

Appropriate PI3K signals generated by the antigen receptor are essential to promote B cell development. Regulation of recombination activating gene (RAG)-1 and RAG-2 expression is one key process that is mediated by PI3K to ensure developmental progression and selection. When PI3K signals are too hi...

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Bibliographic Details
Main Authors: David Benhamou, Verena Labi, Andrew Getahun, Eli Benchetrit, Reem Dowery, Klaus Rajewsky, John C. Cambier, Doron Melamed
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
B cell development
recombination activating gene (RAG)
PI3K–AKT pathway
microRNA
PTEN (phosphatase and tensin homolog)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02715/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02715/full

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