SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation.

SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation.

We have studied the in vivo role of SLIRP in regulation of mitochondrial DNA (mtDNA) gene expression and show here that it stabilizes its interacting partner protein LRPPRC by protecting it from degradation. Although SLIRP is completely dependent on LRPPRC for its stability, reduced levels of LRPPRC...

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Bibliographic Details
Main Authors: Marie Lagouge, Arnaud Mourier, Hyun Ju Lee, Henrik Spåhr, Timothy Wai, Christian Kukat, Eduardo Silva Ramos, Elisa Motori, Jakob D Busch, Stefan Siira, German Mouse Clinic Consortium, Elisabeth Kremmer, Aleksandra Filipovska, Nils-Göran Larsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4527767?pdf=render

Internet

http://europepmc.org/articles/PMC4527767?pdf=render

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