Synthesis and In Vitro Anti-Influenza Virus Evaluation of Novel Sialic Acid (C-5 and C-9)-Pentacyclic Triterpene Derivatives

Synthesis and In Vitro Anti-Influenza Virus Evaluation of Novel Sialic Acid (C-5 and C-9)-Pentacyclic Triterpene Derivatives

The emergence of drug resistant variants of the influenza virus has led to a great need to identify novel and effective antiviral agents. In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activi...

Full description

Bibliographic Details
Main Authors: Xu Han, Long-Long Si, Yong-Ying Shi, Zi-Bo Fan, Shou-Xin Wang, Zhen-Yu Tian, Man Li, Jia-Qi Sun, Ping-Xuan Jiao, Fu-Xiang Ran, Yong-Min Zhang, De-Min Zhou, Su-Long Xiao
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Molecules
Subjects:
pentacyclic triterpene
sialic acid
influenza virus
structure-activity relationship (SAR)
Online Access:http://www.mdpi.com/1420-3049/22/7/1018

Internet

http://www.mdpi.com/1420-3049/22/7/1018

Similar Items