Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling
Tissue engineering-based therapies targeting cartilage diseases, such as osteoarthritis, require in vitro expansion of articular chondrocytes. A major obstacle for these therapies is the dedifferentiation and loss of phenotype accompanying chondrocyte expansion. Recent studies suggest that manipulat...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
AO Research Institute Davos
2017-09-01
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Series: | European Cells & Materials |
Subjects: | |
Online Access: | http://www.ecmjournal.org/papers/vol034/pdf/v034a09.pdf |