Virtual and In Vitro Screens Reveal a Potential Pharmacophore that Avoids the Fibrillization of Aβ1-42.

Virtual and In Vitro Screens Reveal a Potential Pharmacophore that Avoids the Fibrillization of Aβ1-42.

Among the multiple factors that induce Alzheimer's disease, aggregation of the amyloid β peptide (Aβ) is considered the most important due to the ability of the 42-amino acid Aβ peptides (Aβ1-42) to form oligomers and fibrils, which constitute Aβ pathological aggregates. For this reason, the de...

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Main Authors: Maricarmen Hernández-Rodríguez, José Correa-Basurto, María Inés Nicolás-Vázquez, René Miranda-Ruvalcaba, Claudia Guadalupe Benítez-Cardoza, Aldo Arturo Reséndiz-Albor, Juan Vicente Méndez-Méndez, Martha C Rosales-Hernández
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4501547?pdf=render

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http://europepmc.org/articles/PMC4501547?pdf=render

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