Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors.

Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune responses. Antigenic variation of PfEMP1 occurs through in...

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Bibliographic Details
Main Authors: Christian Flueck, Richard Bartfai, Jennifer Volz, Igor Niederwieser, Adriana M Salcedo-Amaya, Blaise T F Alako, Florian Ehlgen, Stuart A Ralph, Alan F Cowman, Zbynek Bozdech, Hendrik G Stunnenberg, Till S Voss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19730695/?tool=EBI