Arachidonic Acid Evokes an Increase in Intracellular Ca<sup>2+</sup> Concentration and Nitric Oxide Production in Endothelial Cells from Human Brain Microcirculation

It has long been known that the conditionally essential polyunsaturated arachidonic acid (AA) regulates cerebral blood flow (CBF) through its metabolites prostaglandin E2 and epoxyeicosatrienoic acid, which act on vascular smooth muscle cells and pericytes to vasorelax cerebral microvessels. However...

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Bibliographic Details
Main Authors: Roberto Berra-Romani, Pawan Faris, Sharon Negri, Laura Botta, Tullio Genova, Francesco Moccia
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/8/7/689