BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

Objective: Pancreatic β-cell dysfunction is a central feature in the pathogenesis of type 2 diabetes (T2D). Accumulating evidence indicates that β-site APP-cleaving enzyme 2 (BACE2) inhibition exerts a beneficial effect on β-cells in different models of T2D. Thus, targeting BACE2 may represent a pot...

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Bibliographic Details
Main Authors: Daniela Díaz-Catalán, Gema Alcarraz-Vizán, Carlos Castaño, Sara de Pablo, Júlia Rodríguez-Comas, Antonio Fernández-Pérez, Mario Vallejo, Sara Ramírez, Marc Claret, Marcelina Parrizas, Anna Novials, Joan-Marc Servitja
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
BACE2
High-fat diet
β-cell proliferation
Insulin secretion
Insulin resistance
Leptin
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782100096X

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http://www.sciencedirect.com/science/article/pii/S221287782100096X

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