Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neuronal and Vascular Damage

Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neuronal and Vascular Damage

Retinal ischemia contributes to visual impairment in ischemic retinopathies. A disintegrin and metalloproteinase ADAM17 is implicated in multiple vascular pathologies through its ability to regulate inflammatory signaling via ectodomain shedding. We investigated the role of endothelial ADAM17 in neu...

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Bibliographic Details
Main Authors: Diana R Gutsaeva, Lamiaa Shalaby, Folami L Powell, Menaka C Thounaojam, Hossameldin Abouhish, Sara A Wetzstein, Ravirajsinh N Jadeja, Hang Fai Kwok, Pamela M Martin, Manuela Bartoli
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
retinal ischemia-reperfusion
ADAM17
vascular permeability
neuronal and vascular degeneration
Online Access:https://www.mdpi.com/1422-0067/21/15/5379

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https://www.mdpi.com/1422-0067/21/15/5379

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