The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons

The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons

Proper transport of the Parkinson’s disease (PD) protein, α-synuclein (α-syn), is thought to be crucial for its localization and function at the synapse. Previous work has shown that defects in long distance transport within narrow caliber axons occur early in PD, but how such defects contribute to...

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Bibliographic Details
Main Authors: Eric N. Anderson, Delnessaw Hirpa, Kan Hong Zheng, Rupkatha Banerjee, Shermali Gunawardena
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
α-synuclein (a-synuclein)
axonal transport disruption
Parkinson’s disease
synaptic abnormality
in vivo imaging
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00540/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00540/full

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