Mechanosensitive Ion Channel Piezo1 Regulates Diet-Induced Adipose Inflammation and Systemic Insulin Resistance

Mechanosensitive Ion Channel Piezo1 Regulates Diet-Induced Adipose Inflammation and Systemic Insulin Resistance

Adipocytes function as an energy buffer and undergo significant size and volume changes in response to nutritional cues. This adipocyte plasticity is important for systemic lipid metabolism and insulin sensitivity. Accompanying the adipocyte size and volume changes, the mechanical pressure against c...

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Bibliographic Details
Main Authors: Can Zhao, Qiushi Sun, Lingyi Tang, Yang Cao, Jamison L. Nourse, Medha M. Pathak, Xiang Lu, Qin Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Endocrinology
Subjects:
adipocytes
insulin sensitivity
Piezo1
inflammation
lipolysis
TLR4
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00373/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00373/full

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