CART cells are prone to Fas- and DR5-mediated cell death

CART cells are prone to Fas- and DR5-mediated cell death

Abstract Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that CART cells progressively upregulate...

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Bibliographic Details
Main Authors: Benjamin O. Tschumi, Nina Dumauthioz, Bastien Marti, Lianjun Zhang, Pascal Schneider, Jean-Pierre Mach, Pedro Romero, Alena Donda
Format: Article
Language:English
Published: BMJ Publishing Group 2018-07-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
CAR T cells
CD8 T lymphocytes
Fas
FasL
Annexin V
Listeria monocytogenes
Online Access:http://link.springer.com/article/10.1186/s40425-018-0385-z

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http://link.springer.com/article/10.1186/s40425-018-0385-z

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