Plasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells

Plasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells

Abstract Background The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and under-investigated. We have hypothesized that plasma exosomes, which play an important role in inter-c...

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Bibliographic Details
Main Authors: Kaiyu Jiang, Rie Karasawa, Zihua Hu, Yanmin Chen, Lucy Holmes, Kathleen M. O’Neil, James N. Jarvis
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Juvenile dermatomyositis
Plasma exosomes
Endothelial cells
Gene expression
RNA-seq
miRNA-seq
Online Access:http://link.springer.com/article/10.1186/s12969-019-0347-0

Internet

http://link.springer.com/article/10.1186/s12969-019-0347-0

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