Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain

Summary: Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of myelin-deficient shiverer mice, rescuing their phenotype and survival. Yet, it has been unclear whether implanted hGPCs are similarly able to remyelinate the diffusely demyelinated adult CNS. We, theref...

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Bibliographic Details
Main Authors: Martha S. Windrem, Steven J. Schanz, Lisa Zou, Devin Chandler-Militello, Nicholas J. Kuypers, Maiken Nedergaard, Yuan Lu, John N. Mariani, Steven A. Goldman
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
glial progenitor
oligodendrocyte progenitor
neural stem cell
demyelinating disease
cuprizone
leukodystrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306112

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http://www.sciencedirect.com/science/article/pii/S2211124720306112

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